Manage lives and Second Chance
The guide reports that a run starts with 10 lives. A loss costs 1 life on days 1–2, 2 lives on days 3–4, and 3 lives from day 5 onward. The first time lives reach zero, Second Chance reportedly returns the run to 1 life and opens a reward event. That makes the day number, not just the number of previous losses, important when judging how much room remains.